New cancer clinical trial: Study of Pembrolizumab (MK-3475) Versus Placebo in Combination With Neoadjuvant Chemotherapy & Adjuvant Endocrine Therapy in the Treatment of Early-Stage Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer (MK-3475-756/KEYNOTE-756)

Published on: October 30, 2018 at 12:00PM
Condition:   Breast Cancer
Interventions:   Biological: Pembrolizumab (K);   Drug: Placebo (P);   Drug: Paclitaxel (X);   Drug: Doxorubicin hydrochloride (A);   Drug: Epirubicin (E);   Drug: Cyclophosphamide (C);   Drug: Endocrine therapy;   Radiation: Radiation therapy;   Procedure: Surgery
Sponsor:   Merck Sharp & Dohme Corp.
Not yet recruiting
https://ift.tt/2Q8FkVi

New cancer clinical trial: Identification of Molecular Biomarkers for Cancer Target Therapy Efficacy

Published on: October 30, 2018 at 12:00PM
Condition:   Cancer
Interventions:   Other: RNA sequencing;   Other: Transcriptome analysis;   Drug: target drug with the score above 0,1;   Drug: target drug with the score equal or below 0,1;   Drug: non-target drug;   Drug: palliative care
Sponsors:   OmicsWay Corp.;   Oncobox Ltd;   Vitamed LLC;   N.N. Blokhin National Medical Research Center of Oncology;   Kaluga Regional Clinical Oncology Center;   Multidisciplinary medical holding SM-Clinic;   Oncological Clinical Dispensary No. 1 of the Moscow City Health Department
Recruiting
https://ift.tt/2qin3K1

New cancer clinical trial: Chemotherapy, Host Response and Molecular Dynamics in Periampullary Cancer

Published on: October 30, 2018 at 12:00PM
Conditions:   Periampullary Adenocarcinoma;   Periampullary Cancer;   Pancreatic Cancer
Intervention:   Drug: Gemcitabine
Sponsor:   Lund University
Recruiting
https://ift.tt/2Q78KDj

New cancer clinical trial: Study to Evaluate the Safety, Tolerability,Pharmacokinetics, and Anti-tumor Activity of a Thorium-227 Labeled Antibody-chelator Conjugate, in Patients With Metastatic Castration Resistant Prostate Cancer

Published on: October 30, 2018 at 12:00PM
Condition:   Metastatic Castration Resistant Prostate Cancer (mCRPC)
Intervention:   Drug: BAY 2315497 Injection
Sponsor:   Bayer
Not yet recruiting
https://ift.tt/2qimYWJ

New cancer clinical trial: Occupational Therapist-Led Work Intervention in Facilitating Work Maintenance or Re-entry to the Workforce in Patients With Stage I to III Breast Cancer Undergoing Chemotherapy

Published on: October 30, 2018 at 12:00PM
Conditions:   Breast Cancer Stage I;   Breast Cancer Stage III;   Breast Cancer Stage II;   Breast Cancer Stage IIA;   Breast Cancer Stage IIB;   Breast Cancer Stage IIIA;   Breast Cancer Stage IIIB;   Breast Cancer Stage IIIc;   Breast Cancer
Interventions:   Behavioral: Occupational Therapy;   Other: Questionnaire Administration;   Other: Quality-of-Life Assessment
Sponsor:   University of Washington
Not yet recruiting
https://ift.tt/2Q7mYEk

New cancer clinical trial: Pembrolizumab and Pelareorep in Treating Patients With Advanced Pancreatic Cancer

Published on: October 30, 2018 at 12:00PM
Conditions:   Pancreatic Adenocarcinoma;   Stage III Pancreatic Cancer AJCC v8;   Stage IV Pancreatic Cancer AJCC v8
Interventions:   Biological: Pembrolizumab;   Biological: Wild-type Reovirus
Sponsors:   Northwestern University;   National Cancer Institute (NCI)
Not yet recruiting
https://ift.tt/2qimVdv

New cancer clinical trial: [68Ga]-NeoBOMB1 Imaging in Patients With Malignancies Known to Overexpress Gastrin Releasing Peptide Receptor (GRPR)

Published on: October 30, 2018 at 12:00PM
Conditions:   Breast Cancer;   Prostate Cancer;   Colorectal Cancer;   Non Small Cell Lung Cancer;   Small Cell Lung Cancer
Intervention:   Drug: [68Ga]-NeoBOMB1
Sponsor:   Advanced Accelerator Applications
Recruiting
https://ift.tt/2Q4PTsB